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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1999 1
2001 1
2003 9
2004 15
2005 26
2006 32
2007 30
2008 31
2009 45
2010 59
2011 76
2012 127
2013 182
2014 240
2015 268
2016 272
2017 283
2018 272
2019 290
2020 289
2021 256
2022 237
2023 221
2024 86

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2,930 results

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Page 1
KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer - practical implications for the clinician.
Afrăsânie VA, Marinca MV, Alexa-Stratulat T, Gafton B, Păduraru M, Adavidoaiei AM, Miron L, Rusu C. Afrăsânie VA, et al. Radiol Oncol. 2019 Sep 24;53(3):265-274. doi: 10.2478/raon-2019-0033. Radiol Oncol. 2019. PMID: 31553708 Free PMC article. Review.
BRAF V600E mutations are rare and occur mostly in tumors located in the ascending colon in elderly female patients. BRAF is instrumental in establishing prognosis: survival is shorter by 10-16 months in BRAF-mutant patients, and BRAF may be a negative …
BRAF V600E mutations are rare and occur mostly in tumors located in the ascending colon in elderly female patients. BRAF is in …
Atypical BRAF and NRAS Mutations in Mucosal Melanoma.
Dumaz N, Jouenne F, Delyon J, Mourah S, Bensussan A, Lebbé C. Dumaz N, et al. Cancers (Basel). 2019 Aug 8;11(8):1133. doi: 10.3390/cancers11081133. Cancers (Basel). 2019. PMID: 31398831 Free PMC article. Review.
Because the Mitogen-Activated Protein Kinase (MAPK) pathway plays such a significant role in melanoma development, we explore v-raf murine sarcoma viral oncogene homolog B (BRAF) and neuroblastoma RAS viral oncogene homolog (NRAS) mutations in mucosal melanoma and c …
Because the Mitogen-Activated Protein Kinase (MAPK) pathway plays such a significant role in melanoma development, we explore v-raf murine s …
Vemurafenib Therapy and BRAF and NRAS Genotype.
Dean L. Dean L. 2017 Aug 15. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. 2017 Aug 15. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. PMID: 28809522 Free Books & Documents. Review.
The label also states that vemurafenib is not indicated for treatment of patients with wild-type BRAF melanoma (3). Variations in NRAS, also an oncogene, are found in up to 30% of all malignancies and in approximately 15-20% of melanomas. NRAS variants activa …
The label also states that vemurafenib is not indicated for treatment of patients with wild-type BRAF melanoma (3). Variations in …
KRAS, NRAS and BRAF mutations in colorectal cancer and melanoma.
Cicenas J, Tamosaitis L, Kvederaviciute K, Tarvydas R, Staniute G, Kalyan K, Meskinyte-Kausiliene E, Stankevicius V, Valius M. Cicenas J, et al. Med Oncol. 2017 Feb;34(2):26. doi: 10.1007/s12032-016-0879-9. Epub 2017 Jan 10. Med Oncol. 2017. PMID: 28074351 Review.
This review focuses on the genes, which are frequently mutated in various cancers and are known to be important in the advance and progression of colorectal cancer and melanoma, namely KRAS, NRAS and BRAF....
This review focuses on the genes, which are frequently mutated in various cancers and are known to be important in the advance and progressi …
Targeted therapies in melanoma beyond BRAF: targeting NRAS-mutated and KIT-mutated melanoma.
Delyon J, Lebbe C, Dumaz N. Delyon J, et al. Curr Opin Oncol. 2020 Mar;32(2):79-84. doi: 10.1097/CCO.0000000000000606. Curr Opin Oncol. 2020. PMID: 31833955 Review.
However, patients with BRAF wild type cannot benefit for such treatments. In this review, we will focus on the current clinical development of targeted therapies beyond BRAF, in NRAS-mutated and KIT-altered melanoma. ...Targeted therapies of KIT-altered melan …
However, patients with BRAF wild type cannot benefit for such treatments. In this review, we will focus on the current clinical devel …
Many Distinct Ways Lead to Drug Resistance in BRAF- and NRAS-Mutated Melanomas.
Vachtenheim J, Ondrušová L. Vachtenheim J, et al. Life (Basel). 2021 May 5;11(5):424. doi: 10.3390/life11050424. Life (Basel). 2021. PMID: 34063141 Free PMC article. Review.
The combat of melanoma by using the targeted therapy is impeded because several major driver mutations fuel its growth (predominantly BRAF and NRAS). Both these mutated oncogenes strongly activate the MAPK (MEK/ERK) pathway. ...Here, we review many of the mechanisms …
The combat of melanoma by using the targeted therapy is impeded because several major driver mutations fuel its growth (predominantly BRA …
BRAF and NRAS prognostic values in conjunctival melanoma: analysis and literature review.
Valentín-Bravo FJ, Pérez-Rodríguez Á, García-Álvarez C, García-Lagarto E, Saornil-Álvarez MA. Valentín-Bravo FJ, et al. Arq Bras Oftalmol. 2023 Oct 13;86(5):e20230071. doi: 10.5935/0004-2749.20230071. eCollection 2023. Arq Bras Oftalmol. 2023. PMID: 35544941 Free article.
Recurrences occurred in all patients with positive BRAF or NRAS mutation, and five of these patients developed systemic dissemination (83.33%). Moreover, four of six patients with mutated BRAF or NRAS (66.66%) had histopathological findings of tumor or …
Recurrences occurred in all patients with positive BRAF or NRAS mutation, and five of these patients developed systemic dissem …
KRAS, NRAS, BRAF, HER2 and MSI Status in a Large Consecutive Series of Colorectal Carcinomas.
Martianov AS, Mitiushkina NV, Ershova AN, Martynenko DE, Bubnov MG, Amankwah P, Yanus GA, Aleksakhina SN, Tiurin VI, Venina AR, Anuskina AA, Gorgul YA, Shestakova AD, Maidin MA, Belyaev AM, Baboshkina LS, Iyevleva AG, Imyanitov EN. Martianov AS, et al. Int J Mol Sci. 2023 Mar 2;24(5):4868. doi: 10.3390/ijms24054868. Int J Mol Sci. 2023. PMID: 36902296 Free PMC article.
This study aimed to analyze clinical and regional factors influencing the distribution of actionable genetic alterations in a large consecutive series of colorectal carcinomas (CRCs). KRAS, NRAS and BRAF mutations, HER2 amplification and overexpression, and microsat …
This study aimed to analyze clinical and regional factors influencing the distribution of actionable genetic alterations in a large consecut …
BRAF, KIT, and NRAS Mutations of Acral Melanoma in White Patients.
Dika E, Veronesi G, Altimari A, Riefolo M, Ravaioli GM, Piraccini BM, Lambertini M, Campione E, Gruppioni E, Fiorentino M, Melotti B, Ferracin M, Patrizi A. Dika E, et al. Am J Clin Pathol. 2020 Apr 15;153(5):664-671. doi: 10.1093/ajcp/aqz209. Am J Clin Pathol. 2020. PMID: 32017841
We sought to describe the mutation profile and clinicopathologic features of AM. METHODS: We investigated BRAF, KIT, and NRAS mutational status in a series of 31 AM samples from white patients. RESULTS: Nodular melanoma was the most common histopathologic subtype (4 …
We sought to describe the mutation profile and clinicopathologic features of AM. METHODS: We investigated BRAF, KIT, and NRAS …
Germline MC1R variants and frequency of somatic BRAF, NRAS, and TERT mutations in melanoma: Literature review and meta-analysis.
Zanna I, Caini S, Raimondi S, Saieva C, Masala G, Massi D, Cocorocchio E, Queirolo P, Stanganelli I, Gandini S. Zanna I, et al. Mol Carcinog. 2021 Mar;60(3):167-171. doi: 10.1002/mc.23280. Epub 2021 Jan 14. Mol Carcinog. 2021. PMID: 33444485 Review.
MC1R gene variants were not significantly associated with the frequency of somatic mutations of the BRAF and NRAS genes. Only three studies focused on somatic mutations of the TERT gene promoter, all of which reported moderate-to-strong positive associations with MC …
MC1R gene variants were not significantly associated with the frequency of somatic mutations of the BRAF and NRAS genes. Only …
2,930 results